Mutations in mtDNA or nuclear DNA, including those involving E3 ubiquitin ligase (Parkin), α-syn, ubiquitin carboxy-terminal hydrolase L1 (UCHL1), parkin-associated protein involved with oxidative stress (DJ1), putative serine threonine kinase (PINK1), auxilin (DNAJC6), synaptojanin 1 (SYNJ1), serine peptidase 2 (HTRA2) and endophilin A1 (SH3GL2), are described in the pathogenesis of Parkinson’s disease [55–59]. Here, SH3GL2 is linked to Parkinson disease.