More interestingly, immunostaining showed that both ARRBs were highly expressed in ionized calcium binding adapter molecule 1 (Iba1)+ microglia (Fig. 1d), but barely in Glial fibrillary acidic protein (GFAP)+ astrocytes (Supplementary Fig. S1a) and neuronal nuclei (NeuN)+ neurons (Supplementary Fig. S1b) in the SNc of LPS- and MPTP-induced PD mice. The gene discussed is AIF1; the disease is Parkinson disease.