Whereas normal B cells (including GC B cells) as well as several types of B-cell non-HLs typically show predominant activation of either the canonical or the non-canonical NF-κB pathway (which is transient in the case of normal B cells), HRS cells show strong concomitant activity of both pathways, further supporting a major role of this pathway in HL pathogenesis [71, 72]. This evidence concerns the gene NFKB1 and Hodgkins lymphoma.