Therefore, the aim of this study was to evaluate the -924 G > A (rs2232365) and -3279 C > A (rs3761548) FOXP3 variants and their association with SLE susceptibility, TGF-β1 plasma levels, presence of autoantibodies and LN, and SLE disease activity index (SLEDAI) in SLE patients. This evidence concerns the gene TGFB1 and systemic lupus erythematosus.