In conclusion, the heritance of at least one A allele of each variant (rs2232365/ rs3761548) increases SLE susceptibility while patients with A/C haplotype in the dominant model had a higher SLEDAI score and patients with ACAC haplotype structure are associated with anti-dsDNA and anti-U1RNP antibodies, and higher susceptibility to nephritis. This evidence concerns the gene SNRNP70 and systemic lupus erythematosus.