According to the study by Drexler et al., Il-1r1−/− and Casp1−/− mice treated with 7,12-dimethylbenz(a)anthracene (DMBA) as an initiator and 12-O-tetradecanoylphorbol-13-acetate (TPA) as a promoter showed the reduced incidence and the multiplicity of skin tumors compared to WT mice, suggesting the tumor supportive role of the IL-1β–IL-1R axis in two-stage skin carcinogenesis74. Here, IL1B is linked to skin neoplasm.