Secretion of pro-inflammatory cytokines, particularly interleukin 1 (IL-1) and 6 (IL-6), and chemokines, such as NF-κB, by tumor cells and tumor-infiltrating lymphocytes stimulates the immune and hematopoietic systems and upregulates the production of CRP, neutrophils, lymphocytes, platelets, and so on20. Here, IL6 is linked to neoplasm.