According to WHO2016, there were 17 AML with mutated NPM1 (mNPM1), 7 AML not otherwise specified (NOS), 2 AML with myelodysplasia-related changes (MRC) and 2 AML with mutated RUNX1 (mRUNX1) patients. Here, NPM1 is linked to acute myeloid leukemia.