GO analysis revealed that BDKRB2 was highly associated with extracellular matrix organization and collagen catabolic process in both pan-glioma and GBM, suggesting that glioma cells through their interactions with BDKRB2 might acquire functions that enhance matrix remodeling, cell migration, invasion, and tumor progression, consistent with the results presented by Montana et al. [28]. This evidence concerns the gene BDKRB2 and central nervous system cancer.