In other types of malignancies, BDKRB2 also exhibited the biological function of promoting cell migration, invasion, and metastasis in hepatocellular carcinoma [12, 13], gastric cancer [14, 16], colorectal cancer [17], prostate cancer [18], head and neck squamous cell carcinoma [20] and chondrosarcoma [21]. Here, BDKRB2 is linked to head and neck squamous cell carcinoma.