Further, as bolstered by the overlapping of H3K27ac peaks with the RELAFUS1 peaks in the 2700081O15Rik gene (Fig. 5c), 2700081O15Rik was remarkably up-regulated in RELAFUS1-driven ependymomas relative to normal brains and PDGFA-driven gliomas (Fig. 5e, f). The gene discussed is PDGFA; the disease is ependymoma.