DOT1L and cancer: We noticed that some RELAFUS1 peaks (TSS ± 10 kb) overlapped with SE regions that were annotated to well-known cancer-associated genes such as CCND1 (a representative NF-κB target gene) [14, 15], PIK3R2 (proto-oncogene), DOT1L (histone modifier gene) in addition to RELA and 2700081O15Rik (mouse homolog of C11orf95) (Fig. 2k; Additional file 10: Table S2F).