Two-way ANOVA comparisons of male and female control and PD patient samples revealed no significant difference in CHCHD2 mRNA levels between sexes [Additional file 1: Fig. S6A, p = 0.65, F (1, 326) = 0.2077], while linear regression analysis revealed no correlation between CHCHD2 mRNA levels and age in either group (Additional file 1: Fig. S6B, control: p = 0.49, R = 0.06; PD: p = 0.35, R = − 0.07). Here, CHCHD2 is linked to Parkinson disease.