AKT1 and cancer: GO and KEGG analyses in endothelial cells indicated that multiple angiogenesis-associated terms were accumulated in the AM_EC group versus the AM_EM group, in addition, CMI- and proliferation-related terms, such as pathways in cancer, positive regulation of cell migration, NF-κB signalling pathway and PI3K-Akt signalling pathway, were also enriched in the comparison (Fig. 3b, c).