MAP1LC3B and Alzheimer disease: We had previously established a mechanistic link between high brain cholesterol and impaired autophagy in AD, showing that cholesterol regulates autophagy through a dual mechanism that elicits autophagosome formation by stimulating the oxidative-mediated lipidation of LC3B but impairs the autophagosome-lysosome fusion by affecting the recycling of key proteins in the fusion process [18].