Accordingly, HDAC6 expression has been reported to be upregulated by 90% in AD hippocampus, co-localizing with MAPT/tau in perinuclear aggresomes [87], and despite its potential protective role in protein aggregates disposal, loss of HDAC6 has been shown to improve AD symptoms in transgenic mouse models [87]. This evidence concerns the gene HDAC6 and Alzheimer disease.