The qRT-PCR results showed that CCNB1, CDK1, and RRM2 were significantly upregulated in liver cancer tumor samples (P < 0.0001; Fig. 7a–c) and cell lines (P < 0.05; Fig. 7d–f) compared with the relevant adjacent non-tumor liver tissues and normal liver cell LO2. This evidence concerns the gene RRM2 and neoplasm.