Some evidence suggested that miR-155-5p has been reported to be involved in HCC progression; Several certain long non-coding RNAs (lncRNAs) inhibit HCC development by sponging miR-155-5p [20]; miR-155-5p also could regulate the aggressiveness of HCC by regulating Wnt/β-catenin signaling or inhibiting PTEN via the PI3K/Akt pathway [21, 22]. The gene discussed is AKT1; the disease is hepatocellular carcinoma.