Mechanically, circTP63 obviously accelerated the HCC proliferation, migration, and invasion, and decreased cell apoptosis by facilitating ZBTB18 expression via sponging miR-155-5p in HCC, and the ZBTB18 expression in HCC tissues was negatively associated with the survival rate of HCC patients, implying that ZBTB1 plays a tumor-promoting effect on HCC progression. This evidence concerns the gene ZBTB1 and hepatocellular carcinoma.