ZBTB18 and hepatocellular carcinoma: In sum, our data firstly determined the expression, clinical implication, and mechanism of circTP63/miR-155-5p/ZBTB18 in HCC, and revealed that circTP63 facilitates HCC progression by regulating the miR-155-5p/ZBTB18 axis, providing promising clinical biomarkers and a therapeutic strategy for the treatment of HCC.