CRP and Increased total leukocyte count: Additionally, the following minor criteria required, recurrent fever, objective finding of abnormal bone remodeling with bone pain (assessed by bone scintigraphy, or MRI), neutrophilic dermal infiltrate on skin biopsy and elevated CRP and/or leukocytosis (CRP of > 30 mg/L, and/or neutrophils of > 10,000/mm3) [4].