All available clinical indicators, including clinicopathological features and biomarkers (Table 1), were subjected to LASSO Cox regression, with a significant correlation between sex, age, tumor size, tumor number, cirrhosis, PVTT, ascites, HBV, HGB, CR, AST, ALB, LDH, γ-GGT, CA199, CRP and OS at minimum values (Fig. 1a). The gene discussed is CRP; the disease is Cirrhosis.