Finally, DOCK4 was recently shown to contribute to low-density lipoprotein transport, a causative process in atherosclerosis progression (90).While these disease indications are promising in the treatment of invasive cancers or cardiovascular disease, the crucial role that DOCK4 plays in neural development implies that there is a delicate balance for homeostatic DOCK4 activity. This evidence concerns the gene DOCK4 and atherosclerosis.