Comparing genes with significantly increased translation in Sun et al. (FDR < 0.05) with those with decreased IR in ALS astrocytes, revealed 44/429 (9%, P = 9.2 × 10−14) overlapping genes, of which 32 are directly relevant to astrocyte reactivity, including OSMR, FBLN5, VIM and PTX3 (Supplementary Table S4) (26). The gene discussed is FBLN5; the disease is amyotrophic lateral sclerosis.