SOD1 and amyotrophic lateral sclerosis: To assess whether IR was also reduced in other ALS mutant astrocytes, we analysed published C9orf72 (66) and SOD1 (8) mutant astrocyte RNA sequencing datasets (C9orf72 dataset: two mutant and two control lines; SOD1 dataset: one mutant and two control lines) (Supplementary Table S1).