ZKSCAN3 and major depressive disorder: In comparison, using local-only models, we identified 5 genes associated with MDD risk at P<2.5×10−6 that persisted after permutation testing; one of these loci showed transcriptome-wide significant associations in the UK Biobank GWAX in the same direction as in PGC (ZKSCAN3, Z = 10.67 in PGC; Z = 5.44 in UK Biobank GWAX).