To estimate the combined effects, all of them used fixed effect (FE) or random effect (RE) models corresponding to the homogeneity or heterogeneity of effects which cannot give the guarantee of model adequacy [133].Therefore, in this paper, an attempt was made to provide a more comprehensive understanding about the association between the IL-6 gene SNPs (rs1800795, rs1800796, rs1800797) and different types of cancer risks, giving the weight on large sample size, more cancer types and appropriate statistical modeling based on the goodness of fit test [133] with the multi-case meta-dataset. The gene discussed is IL6; the disease is cancer.