We found the significant heterogeneity of different studies in the analysis of IL-6 -572G/C polymorphism for overall cancer risk under the all genetic models [C vs. G: Q = 89.96, df = 26, p-value = 0.0001, τ2 = .0391, I2 = 71.04; CC vs. GG: Q = 55.82, df = 26, p-value = 0.0006, τ2 = .1033, I2 = 53.41%; CC vs. CG + GG: Q = 49.23, df = 26, p-value = .0039, τ2 = .0459, I2 = 47.18%; CC + CG vs. GG: Q = 76.19, df = 26, p-value = .0001, τ2 = .0618, I2 = 65.88%; CG vs. CC + GG: Q = 54.40, df = 26, p-value = .0009, τ2 = .0293, I2 = 52.21%]. Here, IL6 is linked to cancer.