CD4 and histoplasmosis: In Mexico, HIV infection is a major health problem, until 2019, a total of 210,931 cases of HIV / AIDS had been reported, and 15,653 new cases were diagnosed and notified that same year.[3] In people living with HIV (PLWHIV) residing in endemics areas, histoplasmosis occurs in 2% to 25%, and might be the first manifestation of AIDS in 50% to 75% of them as progressive disseminated histoplasmosis (PDH).[4] The patients at greatest risk are those with <150 CD4 cells/μL.[5]