SERPINE1 and endometriosis: The increase in PAI-1 expression in the ectopic endometrium might contribute to limiting the invasive potential and proteolytic activity of the ectopic endometrium in adenomyosis, contributing to the deposition of fibrin and extracellular matrix components and finally forming regional lesions in the myometrium, which was similarly reported in advanced stages of endometriosis [27, 28].