Many studies have demonstrated that the mechanisms of apoptosis and necroptosis are related to TNF-α in viral infections (Gyurkovska and Ivanovska 2016) and tumours (Balkwill 2006) and promote a treatment target of TNF-α for these diseases (Monaco et al. 2015); however, in parasitic diseases (Barbosa et al. 2018; Carneiro et al. 2018; de Carvalho and Zamboni 2020; Eugenin et al. 2019; Lee et al. 2019; Zamboni and Lima-Junior 2015) much is still unknown. The gene discussed is TNF; the disease is viral infectious disease.