We further validated these results in study 2 and found that five of these IFN signatures such as IFN-γ response-DN, negative regulation of IFN-γ secretion, IFNG pathway, negative regulation of response to IFN-γ and type 1 IFN biosynthetic process were consistent and significantly higher in asthma (all P-values <0.05) (Figure 2). Here, IFNG is linked to asthma.