The results demonstrated that GCH1, HSP90AB1, HSPA9, KPNA5, NUP85, NUP93, NUP107, NUP188, RANBP2, SEH1L, TUBB, UBA52, and XRCC6 had lower expression levels in asthma, the remaining eight genes CDK1, EIF4E2, GAPDH, MAP3K1, NUP98, NUP214, PPP2CA, and RFC2 had higher expression levels in asthma. The gene discussed is UBA52; the disease is asthma.