CDKN1C and Beckwith-Wiedemann syndrome: CDKN1C is implicated in syndromes associated with intrauterine growth restriction (IUGR) (IMAGE syndrome) (26) and over-growth (Beckwith-Wiedemann syndrome) (27); one of the birth weight SNPs is located 47 146 bp from this gene within an intron of KCNQ1, which is not linked to DDs.