Then, the top 40 hub genes were conducted to evaluate the expression and prognostic values of cervical cancer and 7 upregulated (BUB1, CCNB1, CDK1, AURKB, KIF11, PBK, NUSAP1) and 1 downregulated (ESR1) hub genes were selected to have significant values as biomarkers. The gene discussed is ESR1; the disease is cervical cancer.