The differences between CFTRtm1HGU and wild‐type mice in terms of serum pancreatic enzyme and intrapancreatic trypsin activities in the later (rather than the early) disease course of pancreatitis, as well as the differences in MPO activity in the lungs and pancreas of the animals, suggested that the effects of the CFTR transgene are ultimately connected to infiltrating inflammatory cells. Here, CFTR is linked to pancreatitis.