In support of our studies, reports show that TFEB transfection stimulates lysosome biogenesis and attenuate Aβ generation by accelerating flux through the endosome‐lysosome pathway (Xiao et al., 2015), suggesting that targeting TFEB activation could accelerate removal of Aβ deposits as a veritable arm of a multipronged approach to the treatment of AD. This evidence concerns the gene TFEB and Alzheimer disease.