In addition, activation of H3R downstream signaling CREB, which is involved in improving cognitive dysfunction and Aβ pathology in AD (Wang et al., 2018; Yin et al., 2016), could also up‐regulate autophagy (Chong et al., 2018; Liu et al., 2019; Seok et al., 2014). The gene discussed is CREB1; the disease is Alzheimer disease.