In this study, we identified 390 enriched DEGs including the previously reported CAF marker, ITGA11, and several collagen subtypes including COL11A1 and the representative ligand of ITGA11, COL1A1, as well as 121 depleted DEGs, in 16 paired samples of normal lung fibroblasts and CAFs derived from NSCLC patients. The gene discussed is COL11A1; the disease is non-small cell lung carcinoma.