INS and type 1 diabetes mellitus: In addition, two recent studies identified certain human NLRC4 polymorphisms associated with markers of glucose and lipid metabolism: insulin levels and higher triglyceride levels associated with NLRC4 polymorphisms from a healthy southern Brazil population [20], and positive rate of glutamic acid decarboxylase antibody (GADA) and the onset age associated with rs385076 NLRC4 polymorphism in patients with T1D in a Chinese Han population [21], indicating a clear association between NLRC4 and clinical characteristics of T1D.