Finally, while the ketone body BHB was found to inhibit NLRP3 independently of GPCRs in macrophages and neutrophils, it has recently been reported that in C6 glioma cells, BHB can inhibit NLRP3 through a Gαi‐coupled GPCR, whether that is the BHB Gαi‐coupled receptor GPR109A or not remains to be explored [75]. Here, NLRP3 is linked to glioma.