More specifically, CD5hi human Treg preferentially express ICOS, FOXP3, GITR, and CTLA4 similar to a subpopulation of these cells in mice that are more protective in the context of tissue‐specific autoimmunity and immune homeostasis as compared to their CD5lo counterparts [35, 36]. This evidence concerns the gene TNFRSF18 and Autoimmunity.