This protein activates TGF-β, which is a fibrosis and anti-inflammatory factor, and influences cardiac remodeling by affecting cardiomyocyte apoptosis, myofibroblast differentiation, collagen production, etc. miR-4443 that participates in myocardial fibrosis may be related to the regulation of THBS1/TGF-β signal. The gene discussed is TGFB1; the disease is Myocardial fibrosis.