HIF1A and glioblastoma: Most of GBM leads to upregulating HIF1α.27 We previously reported that the accumulation of 18F-FMISO was significantly correlated with the expression of vascular endothelial growth factor related to HIF1α.11 Therefore, it is reasonable to assume that the accumulation of 18F-FMISO would be high in patients with GBM.