The IDH mutation status was reported to be associated with tumor proliferation and prognosis in lower-grade gliomas.26 Takei et al. reported that 11C-MET could be used to differentiate between AA IDH-mut and AA IDH-wt and between GBM IDH-mut and GBM IDH-wt.22 No report to date has compared the association of 18F-FLT accumulation with tumor prognosis or IDH mutation status. The gene discussed is IDH2; the disease is glioblastoma.