MTOR and central nervous system cancer: Glutamine is a donor of γ-nitrogen to purine and pyrimidine biosynthesis, and contributes to TCA cycle anaplerosis, lipid and protein synthesis, and redox balance.5  IDHmut glioma showed deregulated glutamine metabolism with more reliance on glutamine utilization.11,12 Here, we showed that JHU-083, a glutamine antagonist prodrug, reduces cell proliferation in molecularly diverse cancer cells and decreases mTOR signaling.