MTOR and brain cancer: These mTOR downstream pathways have been implicated in brain cancers.19 The interaction between glutamine metabolism and mTOR signaling is mediated by αKG generated from glutaminolysis and it supports mTORC1 lysosomal translocation and activation.20 The observation that JHU-083 reduced Glu levels representing a potential regulation of mTOR signaling through glutaminolysis.