SUV39H1 and cancer: Protein mass spectrometry and biochemical and molecular experiments showed that FBXO44 forms a repressive epigenetic complex that includes H3K9me3 methyltransferase SUV39H1, ubiquitin ligase CRL4RBBP4/7, and nucleosome deacetylase and chromatin-remodeling complex Mi-2/NuRD, at the replication fork in the cancer cells.