Furthermore, high FBXO44 expression inversely correlated with DNA replication stress, antiviral pathways, IFN signaling, CD8+ T and NK cell infiltration, and tumor antigen presentation in human cancers, corroborating our in vitro data and suggesting that targeting FBXO44/SUV39H1 could enhance tumor cell immunogenicity and immunotherapy response. The gene discussed is SUV39H1; the disease is cancer.