Further studies demonstrated that FBXO44/SUV39H1 inhibition in cancer cells transcriptionally activated various RE subtypes, including satellite repeats, ERVs, and LINE-1, resulting in the accumulation of cytosolic dsRNA and dsDNA replication intermediates and activation of RIG-I/MDA5-MAVS and cGAS-STING antiviral pathways. The gene discussed is SUV39H1; the disease is cancer.