In general, a surplus literature can be found vis-à-vis MBL2 genetic variations and their association with low sMBL levels in susceptibility to many diseases including tuberculosis, malaria, filariasis, systemic lupus erythematosus, trypanosomiasis, rheumatoid arthritis, HIV infection, RVVIs, and many more (as afore referred), not to mention the severe acute respiratory syndrome-coronavirus (SARS-CoV) infection. This evidence concerns the gene MBL2 and systemic lupus erythematosus.