The results showed that the accuracy of CD44 and TGF-B diagnostic markers for differentiationof SCC from dysplastic leukoplakia was 0.984 (95% CI: 0.958-1.016, p< 0.001) and 0.807 (95% CI: 0.643-0.971,p< 0.01), respectively. The gene discussed is TGFB1; the disease is Oral leukoplakia.