Mima et al. [ 30], Ouhtit et al. [ 31], Park et al. [ 32], Anido et al. [ 33] and Bourguignon et al. [ 34] highlighted the important role of CD44 in induction of mesenchymal phenotype mediated by TGF-B such that inhibition of CD44 would inhibit this phenotype and prevent the invasive nature of carcinoma. Here, TGFB1 is linked to carcinoma.