The results showed that the accuracy of CD44 and TGF-B diagnostic markers for differentiation of SCC anddysplastic leukoplakia” from “non-dysplastic leukoplakia and normal mucosa” was 0.984 (95% CI: 0.957- 1.011, p< 0.001)and 0.935 (95% CI: 0.871-0.998, p< 0.001), respectively, and the cutoff point of 1.5 for both tests demonstrated maximum sensitivity and specificity. Here, CD44 is linked to leukoplakia.