In a study sequencing the complementarity-determining region 3 (CDR3) of TCRβ chains isolated from peripheral PD-1+ CD8+ T cells, high PD-1+ CD8+ TCR diversity before anti-PD-1/L1 immunotherapy was positively correlated with PFS and response to therapy in patients with NSCLC. Here, CD8A is linked to non-small cell lung carcinoma.