PDCD1 and renal cell carcinoma: They also observed that antibiotic use in patients with RCC and NSCLC reduced the quantity of Akkermansia muciniphila, which potentiates PD-1 blockade by stimulating IL-12 secretion from dendritic cells and promoting the recruitment of CCR9+ CXCR3+ CD4+ T lymphocytes into mouse tumor beds [108].