ERO1A and Other metabolic disease: Endoplasmic reticulum oxidoreductase 1 alpha (ERO1L), a flavin adenine nucleotide-containing enzyme, is located in the endoplasmic reticulum (ER)—an organelle entrusted with lipid synthesis, calcium storage, and appropriate processing of membrane and secreted proteins for maturation [3] and can be activated by ER stress under hypoxia, metabolic disorders, oxidative stress, or other pathological tumor microenvironment [4, 5].