In a study performed by Abadie et al. (10), following appropriate standardized intrinsic and extrinsic controls (31), there were no HER-2-enriched tumors, in contrast to other studies in which between 5 and 15% of the mammary neoplasms were classified as HER-2 enriched (38, 42, 43). Here, ERBB2 is linked to breast cancer.