VEGFA and neoplasm: Two oncolytic strains of vaccinia virus (strain GLV-1h68 and strain GLV-5b451 expressing GLAF-2, an antibody against VEGF) have been tested against CMC cells in vitro or in xenografted mice, resulting in efficient infection and lysis of cells in vitro while achieving significant tumor growth inhibition in vivo with strong inflammatory and oncolytic-associated effects (368, 369) and a reduction of MVD in the tumors treated with strain GLV-5b451 (337).