After initial reports that showed higher prevalence of use of these medications in COVID-19 patients with cardiac injury and more severe course of disease (8, 9), numerous original studies and meta-analysis reported no relationship with severity or mortality in COVID-19 patients (10, 11) or even benefit of taking renin-angiotensin-aldosterone inhibitors in COVID-19 patients (12, 13). Here, REN is linked to COVID-19.