cmp4 decreases the intrinsic and GEF-mediated nucleotide dissociation and exchange on wild type and G13D mutated Ras proteins, interferes with Ras binding to GEFs (RasGRF1 and Sos1) and the Raf1 effector, and reduces mitogen-activated protein kinases signaling and cell viability of KRasG13D cancer cells. The gene discussed is RAF1; the disease is cancer.