Generally, cancer cells with TMEM16A overexpression due to 11q13 gene amplification exhibit higher proliferative capacity than those without 11q13 gene amplification, since the 11q13 amplicon contains a variety of other genes whose expression may contribute to the cellular changes that drive 11q13 amplified cancer cells to a proliferative state (Huang et al., 2006). The gene discussed is ANO1; the disease is cancer.