MiR-449a suppressed the growth and metastasis of endometrial cancer by directly targeting the NDRG1 gene (Wu et al., 2019) and miR-26a promoted invasion/metastasis by inhibiting PTEN and inhibited cell proliferation by repressing EZH2 in HCC (Zhao et al., 2019). The gene discussed is PTEN; the disease is hepatocellular carcinoma.