ANO1 and pachyonychia congenita: TMEM16A profoundly affects the occurrence, proliferation, and migration of a variety of cancers, including breast cancer(BC) (Wang et al., 2019), prostate cancer (PC), head and neck squamous cell carcinoma (HNSCC), lung cancer (LC) (Hu et al., 2019), colorectal cancer, pancreatic ductal adenocarcinoma (PDAC) (Wu et al., 2017; Song et al., 2018; Finegersh et al., 2017; Jia et al., 2015; Sauter et al., 2015).