Additionally, it is generally accepted that TMEM16A dysfunction is associated with a variety of disease states, including cystic fibrosis, asthma, gastroparesis, hypertension, rotavirus-induced diarrhea and polycystic kidney disease (Zhang et al., 2013; Sondo et al., 2014; Zeng et al., 2018; Ousingsawat et al., 2011; Narayanan et al., 2013; Wang P. et al., 2018). This evidence concerns the gene ANO1 and cystic fibrosis.