ANO1 and cancer: In addition to its importance in the development and progression of cancer, TMEM16A also plays a role in many normal tissues, including transepithelial secretion (Zhang et al., 2015), smooth muscle contraction (Danielsson et al., 2015; Qu et al., 2019), neural development (Hong et al., 2019), and modulation of neuronal excitability and transduction of sensory-stimulation (Ferrera et al,.