Multivariate Cox regression analysis was performed as described above and the differential immune genes obtained were GABRA3, CECR7, TRIM16L, and IL7R. In addition, we performed survival analysis (Kaplan-Meier method) on these four immune genes and found that the mutations in GABRA3, CECR7, TRIM16, and IL7R were related to TMB and promoted anti-tumor immunity. The gene discussed is TRIM16L; the disease is neoplasm.