It was recently reported that when the Caco2 cells were exposed to vesicular stomatitis virus (VSV) particles pseudotyped with chimeric spike from SARS-CoV-2 that carry receptor binding domain (RBD) variant sequences from different betacoronaviruses, appropriate RBD sequence is required for infection whereas most RBD are incompatible with infection (21). Here, CHMP5 is linked to infection.