TNF and COVID-19: Another recent preprint (not peer reviewed) reported that based on proteomic data from 31 COVID-19 patients that identified biomarkers of unbalanced immune system (including IL-1β, IL-6, TNF-α, hsCRP), the screening of a cohort of 990 individuals without infection using the combination of fecal metabolomic analysis and machine learning model, found differences which could be indicative of the predisposition of individuals to inflammation and severe COVID-19 (15).