CD40LG and Sepsis: These molecules also display direct anti-inflammatory effects mediated by Fc receptor consisting in the modulation of dendritic cell function and reduction in response to INF-γ (27), promote the clearance of apoptotic cells, exert an anti-apoptotic action on immune cells, reduce the activity of the classical complement pathway, due prevalently to IgM, stimulate anti-inflammatory cytokines production along with a reduction of the anti-inflammatory ones favoring a balance between activation and suppression of immune response typically defective during sepsis and septic shock.