In this study, comorbidities, a body temperature ≥38.5°C, ln (NLR), ln (PLT), ln (Alb), ln (Tbil), ln (Cr), and ln (CK) were found to be independent risk factors for severe COVID-19, and the CANPT score comprehensively reflected the presence and degree of damage to the immune system, circulatory system, liver, kidneys, and heart in the patients with COVID-19, thereby accurately predicting the risk of severe disease. This evidence concerns the gene ALB and COVID-19.