The factors that independently significantly increased the risk of death were nadir CD4+ T-cell counts being <200 cells/μL, not having medical healthcare insurance, not being on cART, injection drug use, and having one of the following comorbidities: Pneumocystis pneumonia, cryptococcal meningitis, an AIDS malignancy, a non-AIDS malignancy, and kidney disease. The gene discussed is CD4; the disease is Cryptococcal meningitis.