Our study results also showed that factors such as being aged 50 years or older, being urban residents, nadir CD4+ T-cell counts being <200 cells/μL, not being on cART, being injection drug users, and having one of the following comorbidities: Pneumocystis pneumonia, hepatitis C, talaromycosis, non-AIDS malignancy, and kidney disease were independent risk factors for death. The gene discussed is CD4; the disease is kidney disorder.