Mutant p53 was reported to promote metastasis of cancer cells by regulating different pathways, including ZEB1, Rac1, EGFR, NF-Y, and Smad2/3 pathways, which may allow tumor cells to escape from the hypoxic environment (Pitolli et al., 2019; Zhang et al., 2020). This evidence concerns the gene TP53 and neoplasm.