TP53 and cancer: These mutant p53 proteins often accumulate to very high levels in cancer cells through different mechanisms, including posttranslational modifications (such as ubiquitination, acetylation, and phosphorylation), interaction with chaperones and co-chaperone proteins, as well as induction by different stress signals (Muller and Vousden, 2014; Yue et al., 2017; Donehower et al., 2019; Zhang et al., 2020).