TAT-ODD-p53, a p53 fusion protein conjugated with the minimum motif of oxygen-dependent degradation domain (ODD) and the basic domain of the TAT (transactivator of transcription) protein of HIV-1, was reported to induce the cell cycle arrest and apoptosis to inhibit the growth of human lung H1299 cancer cells in a p53-dependent manner especially under hypoxia in vitro. Here, TP53 is linked to cancer.