Besides of the role of p53 in tumor suppression, p53 has also been shown to play important roles in many other biological and pathological processes, such as anti-infection, immune response, maternal reproduction, development, metabolic diseases, ischemia and tissue injuries, neurodegeneration, and aging (Hu, 2009; Levine and Oren, 2009; Vousden and Prives, 2009; Muller and Vousden, 2014; Levine, 2019; Liu J. et al., 2019; Zhang et al., 2020). This evidence concerns the gene TP53 and metabolic disease.