TP53 and neoplasm: In addition to the loss of WT p53 function as a tumor suppressor, many tumor-associated mutant p53 proteins display oncogenic activities, which is known as gain-of-function (GOF), to promote tumor progression by regulating cell proliferation, survival, metastasis, metabolic reprogramming, genomic instability, stemness, tumor microenvironment adaption, and immune evasion (Muller and Vousden, 2014; Donehower et al., 2019; Levine, 2019; Zhang et al., 2020).