Through selective transcriptional induction or repression of these target genes, p53 regulates various cellular responses, including cell cycle arrest, senescence, apoptosis, autophagy, ferroptosis, DNA repair, metabolism, cell migration/invasion, modulation of oxidative stress, etc., which contribute to the role of p53 in tumor suppression (Vousden and Prives, 2009; Muller and Vousden, 2014; Levine, 2019; Liu J. et al., 2019; Liu et al., 2020; Zhang et al., 2020). The gene discussed is TP53; the disease is neoplasm.