Specifically, the activation of Jag1/Notch1 signaling has been associated with chemoresistance in many human tumors, including ovarian cancer (Liu et al., 2014), and the activation of the Notch1 signaling induces resistance to cisplatin (Liu et al., 2013; Wang et al., 2014; Zeng et al., 2020). This evidence concerns the gene NOTCH1 and ovarian cancer.